Excedrin Migraine vs Midol Extended Relief

Last Updated & Fact Checked:  April 18, 2026

Are you trying to decide between the Excedrin Migraine and the Midol Extended Relief?

Product Versus will provide you with all the product details so you can quickly compare the facts to find which product is right for you – the Excedrin Migraine or the Midol Extended Relief – and find out exactly what the differences are.

Both the Excedrin Migraine and the Midol Extended Relief are quality products, so read on to find out which one is best for your needs!

Excedrin Migraine quick facts

Midol Extended Relief quick facts

Excedrin Migraine product details

Bestseller No. 1
Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms - 200 Count
  • One bottle of 2 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms
  • Excedrin Migraine works in 3 ways to relieve migraines: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
  • Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea
  • Excedrin migraine pain relief caplets combine acetaminophen, aspirin and caffeine
  • Head pain relief medicine delivers a powerful triple action formula with two pain relievers and an amplifier
Bestseller No. 2
Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 100 Count
  • One bottle of 100 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms
  • Excedrin Migraine works in 3 ways to relieve migraines: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
  • Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea
  • Excedrin migraine pain relief caplets combine acetaminophen, aspirin and caffeine
  • Head pain relief medicine delivers a powerful triple action formula with two pain relievers and an amplifier
Bestseller No. 3
Excedrin Migraine Relief Caplets for Migraine Symptoms, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 24 Count
  • One bottle of 24 Excedrin Migraine Relief Caplets to Alleviate Migraine Symptoms
  • Migraine medicine that delivers effective migraine headache pain relief
  • Delivers migraine relief, including acting as a migraine headache pain reliever and relieving sensitivity to light and sound, and nausea
  • Excedrin migraine pain relief caplets combine acetaminophen, aspirin and caffeine
  • Delivers a powerful triple action formula with two pain fighters and an amplifier

Midol Extended Relief product details

Bestseller No. 1
Midol Long Lasting Relief 20ct: Midol Long Lasting Relief, Menstrual Symptom Reliever & Fever Reducer, Caplets with Acetaminophen for Menstrual Pain Relief - 20 Count (Packaging May Vary)
  • One box of 20 count Midol Long Lasting Relief Menstrual Pain Relief Caplets with Acetaminophen
  • Effective up to 8 hour pain relief of pain due to premenstrual and menstrual symptoms
  • With extended-release acetaminophen for back pain, muscle pain, headache relief and period pain relief
  • Relieves premenstrual and menstrual symptoms such as pain from period cramps
  • Available in portable and easy-to-take caplet form for menstrual pain relief
Bestseller No. 2
Midol Complete On The Go Caplets with Acetaminophen for Menstrual Symptom Relief, Period Cramp and Menstrual Pain Relief, 50 Count (25 Pouches of 2)
  • Provides PMS headache relief and more: choose Midol Long lasting relief to treat headache, menstrual cramps, backache, and muscle aches due to period.
  • Extra Strength ingredient: Midol Long lasting relief offers an extended release acetaminophen pain reliever that tackles premenstrual headache and cramps for up to 8 hours.
  • For teens and adults: Midol Long lasting relief is recommended for use by adults and children 12 years and older. This means that that teens can rely on Midol Long lasting relief to relieve premenstrual cramps and PMS headache, too.
  • Extra Strength Formula: Midol Complete caplets contain 500 mg of acetaminophen, 60 mg of caffeine, and 15 mg of pyroxamine maleate. Plus, Midol Complete is aspirin-free.
  • Say goodbye to water retention: bloating and water-weight gain are no match for Midol complete's caffeine (diuretic) and antihistamine ingredients.
Bestseller No. 3
Midol Complete Caffeine Free Caplets 24ct: Midol Complete Caffeine Free Menstrual Pain Relief Caplets with Acetaminophen, Provides Headache Relief and Period Cramps Relief, 24 Count
  • MIDOL COMPLETE CAFFEINE FREE, Menstrual pain relief caplets with acetaminophen
  • MENSTRUAL PAIN RELIEF: Provides backache pain relief, headache relief and period cramps relief for up to six hours
  • MULTI-SYMPTOM PERIOD RELIEF: Contains pamabrom to combat bloating and acetaminophen to relieve cramps
  • CAFFEINE FREE: New Midol Complete Caffeine Free also contains 500mg acetaminophen
  • CONVENIENT FORM: Available in portable and easy to take caplet form

New products & alternatives to the Excedrin Migraine and the Midol Extended Relief

New
Excedrin PM for Headache Relief,Acetaminophen 250mg,Aspirin 250mg,Diphenhydramine Citrate 38mg,Pain Reliever,Nighttime Sleep-Aid,24 Count (Pack of 2)
  • The information below is per-pack only
  • One bottle of 24 Excedrin PM Pain Reliever, Headache Relief and Nighttime Sleep-Aid Caplets
  • Pain reliever and nighttime sleeping aid that provides temporary relief of pain associated with headaches and muscle aches accompanied by sleeplessness
  • Caffeine-free diphenhydramine, aspirin and acetaminophen caplets are ideal for nighttime headache sufferers
  • Nighttime Excedrin caplets that relieve headaches fast to help you get to sleep
New
Excedrin Extra Strength - 24 Caplets, Pack of 5
  • Temporarily relieves minor aches and pains due to: headache, a cold, arthritis, muscular aches, sinusitis, toothache, premenstrual and menstrual cramps.
New
Excedrin Extra Strength - 24 Caplets, Pack of 3
  • Temporarily relieves minor aches and pains due to: headache, a cold, arthritis, muscular aches, sinusitis, toothache, premenstrual and menstrual cramps.
New
Excedrin Extra Strength - 24 Caplets, Pack of 2
  • Temporarily relieves minor aches and pains due to: headache, a cold, arthritis, muscular aches, sinusitis, toothache, premenstrual and menstrual cramps.

Our conclusion on the Excedrin Migraine vs Midol Extended Relief

Both the Excedrin Migraine and the Midol Extended Relief are high quality products and we are sure you will be happy with either one. In the end it comes down to your budget and the value for money you are looking for.

Either way, the Excedrin Migraine and the Midol Extended Relief are both excellent products that will more than do their job!