Last Updated & Fact Checked: April 18, 2026
Are you trying to decide between the Excedrin Extra Strength and the Excedrin Sinus Headache?
Product Versus will provide you with all the product details so you can quickly compare the facts to find which product is right for you – the Excedrin Extra Strength or the Excedrin Sinus Headache – and find out exactly what the differences are.
Both the Excedrin Extra Strength and the Excedrin Sinus Headache are quality products, so read on to find out which one is best for your needs!
Excedrin Extra Strength quick facts
Excedrin Sinus Headache quick facts
Excedrin Extra Strength product details
Bestseller No. 1
Excedrin Extra Strength Pain Relief Caplets for Headache Relief, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 200 Count
- One bottle of 200 Excedrin Extra Strength Pain Relief Caplets
- Extra strength pain reliever works fast to relieve headaches
- Excedrin Extra Strength works in 3 ways to relieve headaches: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
- Pain medicine for adults that is clinically proven to provide temporary headache relief, and it temporarily relieves pain associated with colds, menstrual cramps, toothaches, muscular aches and arthritis
- Excedrin Extra Strength caplets contain two pain relievers and a pain relieving aid for enhanced effect
Bestseller No. 2
Excedrin Extra Strength Pain Relief Caplets – Headache Relief – 100 Count
- One bottle of 100 Excedrin Extra Strength Pain Relief Caplets
- Extra strength pain reliever that relieves pain associated with headache, colds, menstrual cramps, toothaches, muscular aches and arthritis
- Excedrin Extra Strength works in 3 ways to relieve headaches: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect
- Pain medicine for adults that is a clinically proven headache pain reliever
- Excedrin Extra Strength caplets contain two pain relievers and a booster for enhanced effect
Bestseller No. 3
Excedrin Extra Strength Caplets for Headache Pain Relief, Acetaminophen 250mg, Aspirin 250mg, Caffeine 65mg, Pain Reliever, 24 count
- One bottle of 24 Excedrin Extra Strength Pain Relief Caplets
- Extra strength pain reliever that relieves pain associated with headache, colds, menstrual cramps, toothaches, muscular aches and arthritis
- Pain medicine for adults that is a clinically proven headache pain reliever
- Excedrin Extra Strength caplets contain two pain fighters and a booster for enhanced effect
- Pain reliever available in convenient caplet form
Excedrin Sinus Headache product details
Bestseller No. 1
Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct
- 24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
- Pain reliever and nasal decongestant formulated to temporarily reduce fever and relieve symptoms of nasal congestion, sinus headache and pressure
- Each sinus relief caplet contains 325 milligrams of acetaminophen to temporarily relieve pain and reduce fever as well as 5 milligrams of phenylephrine HCl, a nasal decongestant to help clear nasal passages
- The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages
- From the #1 doctor recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief
Bestseller No. 2
Excedrin Tension Headache Relief Caplets, Acetaminophen 500mg, Caffeine 65mg, Pain Reliever, Aspirin-Free, 100 Count
- One bottle of 100 caplets of Excedrin Tension Headache Relief Caplets Without Aspirin for Head, Neck and Shoulder Pain Relief
- Aspirin-free tension headache pain medicine that quickly relieves headaches and pain caused by tension and stress
- Delivers muscle ache, shoulder and neck pain relief
- Combines acetaminophen with caffeine to temporarily relieve pain caused by headaches and muscle aches
- Contains a trusted formula that combines a pain reliever and an amplifier
Bestseller No. 3
Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct
- DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
- NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus, helps relieve sinus pressure and sinus headaches
- PHENYLEPHRINE & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant that provides non-drowsy relief, plus, 325 mg of acetaminophen, a pain and fever reducer
- HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time period
- FSA HSA APPROVED PRODUCT: Sinus congestion relief and pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible. Product eligibility may vary by plan
New products & alternatives to the Excedrin Extra Strength and the Excedrin Sinus Headache
New
Excedrin PM for Headache Relief,Acetaminophen 250mg,Aspirin 250mg,Diphenhydramine Citrate 38mg,Pain Reliever,Nighttime Sleep-Aid,24 Count (Pack of 2)
- The information below is per-pack only
- One bottle of 24 Excedrin PM Pain Reliever, Headache Relief and Nighttime Sleep-Aid Caplets
- Pain reliever and nighttime sleeping aid that provides temporary relief of pain associated with headaches and muscle aches accompanied by sleeplessness
- Caffeine-free diphenhydramine, aspirin and acetaminophen caplets are ideal for nighttime headache sufferers
- Nighttime Excedrin caplets that relieve headaches fast to help you get to sleep
New
Excedrin Extra Strength, Acetaminophen, Aspirin (NSAID) and Caffeine, 24 ct (Pack of 4)
- Powerful Combination of Three Active Ingredients: Acetaminophen, Aspirin (NSAID), and Caffeine
- Easy-to-Swallow Caplets
- Effective for Various Types of Discomfort
- Convenient Easy-to-Swallow Caplets
- Designed for fast comfort
New
Excedrin Extra Strength - 24 Caplets, Pack of 5
- Temporarily relieves minor aches and pains due to: headache, a cold, arthritis, muscular aches, sinusitis, toothache, premenstrual and menstrual cramps.
New
Excedrin Extra Strength - 24 Caplets, Pack of 3
- Temporarily relieves minor aches and pains due to: headache, a cold, arthritis, muscular aches, sinusitis, toothache, premenstrual and menstrual cramps.
Our conclusion on the Excedrin Extra Strength vs Excedrin Sinus Headache
Both the Excedrin Extra Strength and the Excedrin Sinus Headache are high quality products and we are sure you will be happy with either one. In the end it comes down to your budget and the value for money you are looking for.
Either way, the Excedrin Extra Strength and the Excedrin Sinus Headache are both excellent products that will more than do their job!